The mammary myoepithelial cell was named the cinderella of mammary cell biology in light of the earlier focus on the luminal cell. Mec generally arises from the parotid gland 2982 % of all cases and rarely from the submandibular gland, minor salivary glands, or the upper respiratory tract 24. Saliva is a fluid secreted by the salivary glands that keeps the oral cavity moist and also coats the teeth along with mucosa. Differential ckit expression pattern in major salivary glands. The importance of being a myoepithelial cell breast. These may be positive for alpha smooth muscle actin and can contract and expel the secretions of exocrine glands. To date, no definitive therapeutic approach can compensate the impairment of salivary glands, and treatment are purely symptomatic. Epithelial myoepithelial carcinoma emc is a rare salivary gland malignancy comprising less than 1% of all salivary gland neoplasms. Myoepithelioma is usually a benign tumor arising from neoplastic myoepithelial or basket cells which are found between the basement membrane and the basal.
Myoepithelial cell an overview sciencedirect topics. To investigate the lineage potential of k5expressing intercalated duct cells, we crossed the krt5 creer mouse, carrying a tamoxifeninducible cre recombinase creer, with the r26 tdtomato reporter strain. Immunohistochemistry of myoepithelial cells during development of. Histologically, all the tumours were composed of small ducts with a double cell lining surrounded by a basement membrane. The inner cells were epithelial and the outer cells myoepithelial, the latter usually. Thirteen men and 12 women aged 24 to 77 years mean age, 55 yrs participated in the study, and most presented with a painless mass. Cells demonstrate plasticity following injury, but the extent of this phenomenon and the cellular mechanisms involved remain underexplored. Myoepithelial cells mecs are considered to be a key participant in most salivary gland diseases, particularly tumors.
The histopathology shows several architectural patterns such as trabecular, glandular, partly cystic, and solid. Clear cell carcinoma consists exclusively of luminal. In salivary glands and other exocrine glands, there are starshaped cells lying between the basal lamina and the acinar and ductal cells. Diagnostic dilemmas caused are due to inadequacy of characterizing. Epithelialmyoepithelial carcinoma of the salivary glands. They are preponderantly tumors of the parotid glands with a relatively low mortality but a decided locoregional aggressiveness. Epithelialmyoepithelial carcinoma comprises intercalated ductlike structures with an inner component of epithelial cells, surrounded by an outer component of clear myoepithelial cells. Vimentin as a marker of myoepithelial cells in salivary gland. Although some case series exist, the clinical features of mec vary considerably depending on the site of origin.
Epithelial myoepithelial carcinoma of the salivary glands emc is a rare neoplasm first described by don ath et al. Its longterm prognosis remains unknown because of the paucity of reported cases with longterm followup. Vimentin as a marker of myoepithelial cells in salivary. The samples analyzed included tumors in which the participation of myoepithelial cells as a tumoral component has been postulated, i. We compared the immunoexpression of 5 myoepithelial cell mec markers.
Secretions from glands are expelled by the contractile function of myoepithelial cells. The cystic lesion has a mildly fibrotic appearing wall, is lined by histiocytes intermixed with rare lymphocytes, and contains mucous and macrophages. Isolated human submandibular gland stemprogenitor cells hsmgepispcs were. Effects of benzodiazepines on acinar and myoepithelial cells. Epithelialmyoepithelial carcinoma of the salivary glands emc is a rare neoplasm first described by don ath et al. Nov 18, 2016 myoepithelial carcinoma is a rare malignant cancerous tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues. Other than the head and neck, mec has been reported in the lung, breast, bronchus, mediastinum. Epithelialmyoepithelial carcinomas comprise approximately 1 % of all salivary gland neoplasms. To clarify the discrepancy between ckit immunoreactivity of tissue and single cell suspensions of adult smgs, we used a. Invasive myoepithelial carcinoma ex pleomorphic adenoma of.
Epithelialmyoepithelial carcinoma of salivary glands john. The myoepi cells lining the ducts are spindleshaped cells,oriented parallel to the long axis of ducts as a continuous layer. Myoepithelial cells of salivary glands have a complex. Only 1% of all salivary gland neoplasms are myoepitheliomas.
Epithelial myoepithelial carcinomas comprise approximately 1 % of all salivary gland neoplasms. Myoepithelial carcinoma mec is a rare salivary gland tumor, accounting for 0. Khademi b, kazemi t, bayat a, bahranifard h, daneshbad y, mohammadianpanah m. Current perspectives in salivary gland tumors c pramod redder 1, v suresh kandagal 1, nupura vibhute 1, pramod s ingaleshwar 2, sharan j shetty 2, sameer ahamad 3 1 department of oral pathology and microbiology, school of dental sciences, krishna institute of medical sciences university, karad, maharashtra, india 2 department of oral pathology and microbiology, a. Research article proliferative activity of myoepithelial cells in. K5k14positive cells contribute to salivary glandlike. Ip045, spindle cell myoepithelioma of the parotid gland.
Fineneedle aspiration of epithelialmyoepithelial carcinoma. Epithelialmyoepithelial carcinoma of the parotid gland. Organ replacement regenerative therapy based on human adult stem cells may be effective for salivary gland hypofunction. Dec 01, 2018 myoepithelial carcinoma of salivary gland is a malignant epithelial tumor, composed almost only of myoepithelial cell type, affecting either the major or minor salivary glands. These tumors arise from portions of the salivary duct system in. Myoepithelial cells mecs are found in multiple glandular organs such as the lacrimal, salivary, harderian, sweat, prostate, and mammary glands. In some tumors of the salivary glands, myoepithelial cells do not participate in histogenesis. Jul 10, 2015 myoepithelial cells mecs are found in multiple glandular organs such as the lacrimal, salivary, harderian, sweat, prostate, and mammary glands. Myoepithelial carcinoma can arise in both minor and major salivary glands but with a predilection for the parotid gland. In salivary glands and other exocrine glands, there are starshaped cells lying.
Mar 20, 2020 organ replacement regenerative therapy based on human adult stem cells may be effective for salivary gland hypofunction. A variety of diseases, such as cancer, autoimmune diseases, infections and physical traumas, can alter the functionality of these glands, greatly impacting the quality of life of patients. Mc usually presents as a slowgrowing painless mass arising in the parotid gland, but may involve other. Mar 01, 2015 myoepithelial cells mec are found in the secretory units of many mammalian exocrine glands such as mammary, sweat, lacrimal and salivary glands. Sep 21, 2018 ckit is broadly expressed in the major salivary glands of adult mice. Epithelialmyoepithelial carcinoma emc of salivary gland is a malignant epithelial tumor, composed of two distinct cell types, affecting either the major or minor salivary glands. It is noteworthy that myoepithelial cells of the salivary glands are located between the basal layer and plasmatic membrane of the secretory acinar cells and interspersed ducts klein, 2002. Read innervation and myoepithelial arrangements in the submandibular salivary gland of ferret investigated by enzyme, catecholamine and filament histochemistry, archives of oral biology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The myoepi cells in tdlus discontinuous, stellate shaped and form a.
Normal and neoplastic myoepithelial cells in salivary glands. Limited regeneration of adult salivary glands after severe. Myoepithelial cell, neoplasm, salivary gland tumor. They envelop the glandular, acinar, and ductal elements of various organs, especially breast and salivary glands. Myoepithelial cells are ectodermally derived contractile cells that act as smooth muscle cells. Its designation stresses the cellular com position of the neoplasm, as a carcinoma made by duct epithelial cells and myoepithelial cells corio et al. Pdf myoepithelial cells are normal constituent of the salivary acini and smaller ducts, and are found between. Mecs play an important role in supporting the morphogenesis, differentiation and polarization of salivary acini. Infiltrating spindle cells with fibrillar eosinophilic cytoplasm tumor appears to arise from myoepithelial cells of ductules at periphery of lesion cells have variable atypia mitotic figures common, but may be less than 410 hpf may have clear cells tohoku j exp med 2003. Salivary gland myoepithelial carcinoma mc or malignant myoepithelioma is a rare entity. We report a case of cutaneous myoepithelial carcinoma in a 47yearold man with a history of endstage renal disease and renal transplant 19 years prior who presented to the hospital with a 3month history of diffuse bone pain and an ulcerated scalp mass with multiple.
The importance of being a myoepithelial cell breast cancer. These glands are divided into numerouslobules which contain the secretory units, which are called acini. The primary pulmonary myoepithelial carcinoma is a rare neoplasm that is thought to arise from the submucosal bronchial glands of the lower respiratory tract, which are considered as a form of minor salivary glands. Generation of functional salivary gland tissue from human. Primary cutaneous neoplasms of myoepithelial differentiation are uncommon.
R26 tdtomato mice, persistent and heritable tdtomato. Myoepithelial cells sometimes referred to as myoepithelium are cells usually found in glandular epithelium as a thin layer above the basement membrane but generally beneath the luminal cells. The myoepithelial cell at a glance myoepi cells are attached to the basement memb by hemidesmosomes adjacent luminal epithelial cells by desmosomes. Epithelialmyoepithelial carcinoma of the parotid gland author. Neoplastic myoepithelial cells in both benign and malignant tumours can take several forms, including epithelioid. Primary clear cell tumors of the salivary glands include epithelialmyoepithelial carcinoma, clear cell carcinoma, and clear cell myoepithelial carcinoma. Myoepithelial cells surround the acini but have also been found around intercalary and striated ducts.
However, the generated tissues are immature because the signaling factors that induce the differentiation of human salivary gland stem cells into salivary glands are unknown. For most of these, the original diagnosis was malignant mixed tumor. Physiology, pathology and regeneration of salivary glands. Myoepithelial cell markers in salivary gland neoplasms. Pdf spindle cell myoepithelioma of the parotid gland. Approximately 66% of these tumors occur in a part of the salivary gland, known as the parotid gland. Four cases of epithelial myoepithelial carcinoma of the salivary glands arose as painless masses in patients over 60 years old, three in the parotid and one in the submandibular gland. Jan 29, 20 the myoepithelial cell at a glance myoepi cells are attached to the basement memb by hemidesmosomes adjacent luminal epithelial cells by desmosomes. Myoepithelial carcinomas are described as the malignant version of benign myoepitheliomas.
Apr 23, 2015 in salivary glands and other exocrine glands, there are starshaped cells lying between the basal lamina and the acinar and ductal cells. We compared the immunoexpression of 5 myoepithelial cell mec markers asmoothmuscle actin, calponin, hcaldesmon, vimentin, and s100protein using 16 pleomorphic adenomas pa, 15 adenoid cystic carcinomas acc, and 3 epithelialmyoepithelial carcinomas emc of salivary glands. Myoepithelial cells are found in exocrine glands, including highly developed glands, such as the breast, where they form a major population surrounding glandular acini and ducts, and squeeze secretions from the glandular lumina. Isolated human submandibular gland stemprogenitor cells hsmgepispcs were characterized and three. Pathophysiology of myoepithelial cells in salivary glands. Myoepithelial carcinoma of salivary gland is a malignant epithelial tumor, composed almost only of myoepithelial cell type, affecting either the major or minor salivary glands. It is assumed that they take part in the expulsion of the saliva, and possibly they support. Four cases of epithelialmyoepithelial carcinoma of the salivary glands arose as painless masses in patients over 60 years old, three in the parotid and one in the submandibular gland. The normal salivary glands were divided into four cases of parotid gland obtained from pleomorphic adenoma from outside the capsule ihrler et. Myoepithelial cells are believed to be of ectodermal origin. Neoplastic myoepithelial cells in both benign and malignant tumours can take several forms, including epithelioid, spindle. Epithelialmyoepithelial carcinoma of salivary glands. Myoepithelial cells mec are found in the secretory units of many mammalian exocrine glands such as mammary, sweat, lacrimal and salivary glands. Myoepithelial carcinoma an overview sciencedirect topics.
Myoepithelial cells are a normal constituent of the salivary acini and smaller ducts, and are found between the epithelial cells and the basement membrane. Around acini, myoepithelial cells have a stellate, multiprocessed morphology in three. Epithelialmyoepithelial carcinoma of salivary gland. Myoepithelial cells normally surround ducts in secretory organs, such as the breasts, salivary glands, and cutaneous sweat glands. Myoepithelial cell markers in salivary gland neoplasms cristiane.
They are interposed between the secretory cells and the basal lamina. These are characterized by high expression of actin and myosin myofilaments in their cytoplasm, which make their contractility one of their main functions. Myoepithelial neoplasms are well recognized in the salivary glands 14,15. The sections show a stratified squamous epithelium with a thin layer of parakeratosis, minor salivary glands, and a wellcircumscribed cystic lesion.
Outer tubular cells of organoid doublelayered tubular structures seen in pleomorphic and monomorphic adenoma and adenoid cystic carcinoma, and cystlining. In salivary glands, the myoepithelial cells that surround the intercalated ducts are spindled in contrast to the large stellate ones that envelop the acini. The protein p63 was present in all stages of salivary gland morphogenesis from initial bud to terminal bud stage. Salivary glands are composed mainly of parenchymal cells acini and myoepithelial cells mecs. Therefore, accumulation of these rare cases is important.
Myoepithelial cells do not have a demonstrable secretory capability, but they can store glycogen in abundance. The cells that are found in the connective tissue of the salivary glands are similar to those in other connective tissues of the body and include broblasts, macrophages, mast cells, histology 70. Pdf pathophysiology of myoepithelial cells in salivary glands. Cd29, s100 and calponin were detected increasingly as salivary gland structure matured and in fully developed salivary gland. Primary pulmonary myoepithelial carcinoma interactive. It is observed in a wide age category of children and adults. Myoepithelial carcinoma of the retromolar area in a young female. Pdf epithelialmyoepithelial carcinoma of the parotid gland. They can be recognized with various immunohistochemical markers, although none is specific or reliable in every case. The physiological role of these cells in salivary glands is remarkably little known. Cutaneous myoepithelial carcinoma with disseminated.
Mammary myoepithelial cells have recently been described as natural tumour suppressors. Myoepithelial carcinoma is a rare malignant cancerous tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues. It is assumed that they take part in the expulsion of the saliva, and possibly they support the structures against a distension during secretion. Oct 28, 2016 myoepithelial carcinoma mec is a rare salivary gland tumor. Various benign and malignant tumors of these structures have occasionally been reported in the lung.
Proteins gfap, cd10 and caldesmon were not observed in myoepithelial cells of salivary glands. We now need to understand more about their origin and to reconsider their place in the complex process of mammary morphogenesis. Mecs structurally resemble both epithelial cells and smooth muscles. In adult salivary glands, k5 expression is restricted to intercalated and basal excretory ducts and myoepithelial cells. Salivary glands are essential structures in the oral cavity. Salivary glandlike tumors of the breast show a great variety of architectural patterns and cellular differentiations such as glandular, myoepithelial, squamous, and even mesenchymal phenotypes.
Pdf download for myoepithelial cell markers in salivary gland neoplasms. They are found in the sweat glands, mammary glands, lacrimal glands, and salivary glands. Sep 10, 2018 epithelial myoepithelial carcinoma emc of salivary gland is a malignant epithelial tumor, composed of two distinct cell types, affecting either the major or minor salivary glands. The salivary gland possesses tubuloacinar units, and these are merocrine. It also consists of branched ducts for the passage of the saliva. Myoepithelial cells mec of the salivary glands in health. The structure and function of myoepithelial cells in.
They are preponderantly tumors of the parotid glands with a relatively low mortality but a decided lo. These cells structurally resemble epithelial cells and smooth muscles and, thus, are referred to as myoepithelial cells mecs. To describe the clinical and cytopathologic findings in 15 cases of salivary gland myoepithelial neoplasms and to assess. Know the localization of myoepithelial cells and nerves in relation to the acinar cells, and their role in secretory functions. Epithelialmyoepithelial carcinoma emc is a rare salivary gland malignancy comprising less than 1% of all salivary gland neoplasms. Myoepithelial tumours of the salivary glands current. The common developmental origin of myoepithelial cells with the basal cells of the larger ducts is displayed in the mature glands by shared structural and immunohistochemical features, although most such basal cells do not have the distinguishing features of myoepithelial cells, such as myofibrils. Pathophysiology of myoepithelial cells in salivary glands ncbi. These cells surround glandular secretory epithelium.
38 362 1111 21 723 39 953 897 152 820 1397 1365 1211 16 1158 899 331 1440 1560 1328 154 218 831 383 1302 1367 1225 1474 490 693 1045 1392 549 109 983